Personalized compounding · Prescription required

Compounded Low-Dose Naltrexone (LDN)

Trinova Health prepares patient-specific low-dose naltrexone in the strength and dosage form authorized by a licensed prescriber. Our pharmacy team can answer formulation questions and help coordinate a new prescription or transfer.

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Final availability, price, beyond-use date, and formulation depend on the valid prescription and pharmacy review.

Next steps

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Send Trinova Health your prescription details, or ask us to coordinate a transfer from another pharmacy.

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Call to discuss prescription intake, formulation questions, shipping, or account setup.

Call 844-219-2139

Important

A Valid Prescription Is Required

Trinova Health compounds medication only after receiving a patient-specific prescription from a licensed practitioner.

  • Your practitioner may send the prescription directly.
  • Our team can help coordinate a pharmacy transfer.
  • Formulation and directions must match the prescriber’s order.
  • Medication is dispensed only after pharmacist review.
For licensed practitioners

Send a Prescription to Trinova Health

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Electronic Prescription

Search for Trinova Health in Tampa, Florida, within your e-prescribing system.

Fax

Fax the patient-specific prescription to 888-288-8253.

Need a different formulation?

Ask About a Patient-Specific Strength or Dosage Form

Availability is evaluated by the pharmacist and must be supported by a valid prescription.

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Medication information

Low-Dose Naltrexone Overview

This educational information does not replace the instructions or clinical judgment of the prescribing practitioner or dispensing pharmacist.

What is low-dose naltrexone?

Naltrexone is an opioid receptor antagonist. FDA-approved oral naltrexone products use a standard dose for alcohol dependence and blockade of the effects of externally administered opioids. “Low-dose naltrexone” describes substantially smaller doses that clinicians may prescribe off-label for selected patients.

Evidence and regulatory status

Low-dose naltrexone is not FDA-approved for chronic pain, fibromyalgia, autoimmune disease, or other commonly discussed off-label uses. Published studies have produced mixed results, and the strength of evidence varies by condition. Treatment decisions should be individualized by the prescriber.

Compounded preparation

A compounded LDN prescription may be useful when the prescribed strength or dosage form is not commercially available. The active ingredient, capsule or tablet composition, and inactive ingredients are selected according to the prescription and pharmacy review.

Use exactly as prescribed

  • Take the medication only in the dose, dosage form, and schedule written by your prescriber.
  • Do not increase, decrease, split, crush, or discontinue the medication unless instructed.
  • Ask the pharmacist whether your formulation should be taken with food and how it should be stored.
  • Contact your prescriber or pharmacist after a missed dose rather than doubling the next dose.
Opioid-free interval: Naltrexone can precipitate severe withdrawal in a person who is physically dependent on opioids. FDA labeling for standard oral naltrexone recommends an opioid-free interval of at least 7–10 days after short-acting opioids; a longer interval may be needed after methadone or buprenorphine. The prescriber must determine when it is safe to begin.

Do not combine with opioid medicines unless specifically managed by a clinician

Naltrexone blocks opioid receptors and may reduce the effect of opioid pain medicines, cough medicines, or antidiarrheal products. Starting naltrexone too soon after opioid use may trigger abrupt withdrawal.

Tell your healthcare team before treatment if you:

  • Use prescription opioids, tramadol, buprenorphine, methadone, or opioid-containing cough or diarrhea medicines.
  • Have liver disease, abnormal liver tests, kidney disease, or another significant medical condition.
  • Are pregnant, planning pregnancy, breastfeeding, or treating a child.
  • Expect surgery, dental work, emergency treatment, or another situation in which pain medication may be required.

Seek urgent medical help for:

Signs of a severe allergic reaction, severe or persistent abdominal pain, symptoms of acute hepatitis such as yellowing of the skin or eyes, severe depression or suicidal thoughts, or symptoms of precipitated opioid withdrawal.

Possible adverse effects

Reported effects with naltrexone may include nausea, stomach discomfort, headache, dizziness, fatigue, nervousness, sleep changes, or vivid dreams. The likelihood and severity can differ by patient and dose.

Contact the prescriber or pharmacist about any persistent, worsening, or unexpected reaction. This page does not list every possible adverse effect or interaction.

Active ingredient

Naltrexone hydrochloride, in the patient-specific strength stated on the prescription label.

Inactive ingredients

Inactive ingredients vary by formulation and may include capsule shells, fillers, binders, flavoring agents, or suspending vehicles. Tell Trinova Health about allergies or sensitivities before the prescription is prepared.

Storage and shipping

Follow the storage directions printed on the prescription label. Protect the medication from conditions listed on the label, keep it out of reach of children and pets, and review Trinova Health’s shipping policies for current delivery information.

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Questions About a Low-Dose Naltrexone Prescription?

Our pharmacy team is available to help patients and practitioners with prescription intake and formulation questions.

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