Low Dose Naltrexone Frequently Asked Questions

Low Dose Naltrexone (LDN) is a therapy that many patients new to it have questions about. Since LDN is not widely marketed, reliable info can be hard to find. Here, we answer common questions to help you understand LDN better.

  • What are the side effects of Low Dose Naltrexone (LDN)?
    Most patients experience little to no side effects. The main side effect is sleep changes. Some sleep more deeply, while others may have trouble staying asleep. About 5% of patients report sleep issues, but switching LDN to morning can help. Overall, many find improved sleep quality.
  • Is LDN expensive at Trinova Health?
    Our pharmacy offers LDN for under $1 per day. Monthly cost ranges from $20 to $27.50 depending on strength. Discounts for 2 or 3 month supplies are also available to save you more.
  • Does insurance cover LDN?
    Typically, insurance does not cover compounded drugs like LDN. Check your plan to be sure. Many patients use FSA/HSA cards to pay for it, which are usually accepted.
  • How long does LDN take to work?
    Results vary: some feel better the next day, but most see improvement in 2-4 weeks. For some, it may take months. If no effect, speak to your doctor about adjusting dose or timing.
  • Could LDN cause my side effect?
    To test if LDN is causing a side effect, stop LDN for a few days. If symptoms vanish and return when restarting, LDN is likely the cause.
  • Why haven’t I heard about LDN before?
    LDN is not mass produced or marketed. Many doctors are unaware since it is not taught in medical schools and FDA approval only covers high dose use for alcoholism.
  • Why did my doctor prescribe LDN?
    LDN is commonly prescribed for autoimmune diseases like Hashimoto’s, MS, Chronic Fatigue Syndrome, and Rheumatoid Arthritis. It may also support weight loss and other conditions.
  • What conditions can LDN be prescribed for?
    LDN may help with conditions including: Ankylosing Spondylitis, Behcet’s Disease, Celiac Disease, Chronic Fatigue Syndrome, Crohn’s Disease, Fibromyalgia, Hashimoto’s, IBS, Rheumatoid Arthritis, Lupus, Ulcerative Colitis, and others.
  • Does LDN help with chronic pain?
    Many patients report pain relief with LDN, likely due to increased endorphins. No patients have reported pain worsening from LDN.
  • Does naltrexone cause weight loss?
    Naltrexone is known to aid weight loss by reducing cravings and hunger, which is why it’s combined with other meds like Bupropion.
  • Is Trinova Health experienced with LDN?
    Yes, we have helped thousands with our LDN formulations and look forward to assisting you.

Important: LDN is not FDA approved for the conditions listed here and safety or efficacy is not evaluated by the FDA for these uses. It is only FDA approved in higher doses for alcoholism. Always consult your doctor before starting any medication.

Have more questions about LDN? Use our contact form and one of our clinical pharmacists will get back to you promptly. Next, learn what to avoid when taking low dose naltrexone to maximize its effectiveness. Discover the comprehensive benefits of low dose naltrexone and its role in IBS and Crohn’s management.

Last updated June 19, 2026

For more detailed information on Low Dose Naltrexone (LDN), visit our comprehensive LDN insights page. To understand precautions, check what to avoid when taking LDN and explore the benefits of LDN.

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